Fig.2 Significant positive association between TSPs and marker genes related to epithelial-mesenchymal transition and immune cell infiltration.

(A) The heatmap displayed the biological pathways significantly enriched by the five TSPs molecules. (|NES|>1, p.adjust<0.05). (B&C) The enriched biological pathways based on GO and KEGG. (D) The co-expression relationship between TSPs and differentially expressed EMT markers in colon cancer (*, p < 0.05; **, p < 0.01;  ***, p < 0.001). (E&F) The analysis of the correlation between TSPs and immune molecules/cells using ssGSEA  (*, p < 0.05; **, p < 0.01;  ***, p < 0.001).

Figure S2. TSPs is significantly associated with cancer progression-related genes.

(A) The venn plot illustrates the 116 differential genes shared by the TSPs. (B) Molecules closely related to TSPs function (rendered by cytoscape). The size and color of the circles in the interaction network were adjusted to reflect the degree of the association. (C) Co-expression of TSPs with TIMP, MMP and UPA, box colors are based on correlation coefficients.