Fig. 7: THBS2-Mediated Impact on Cancer-Associated Fibroblasts (CAFs) in the Tumor Microenvironment (TME).

(A) Significant THBS2-mediated impact on the communication between CAFs and other cells in the TME(p < 0.05) , as determined by Seurat analysis in the cohort(GSE166555,n=12) . (B) The pair number of receptor-ligand interactions between multiple cell types. (C) Box plot showing the expression of T-cell exhaustion markers in THBS2-H and THBS2-L groups within the TCGA cohort. (D) Differences in Hallmark pathway score between THBS2⁺ and THBS2^- CAFs assessed through GSVA within the TCGA cohort. (E) Differences in the mean expression levels of receptor-ligand pairs involved in the Hedgehog and TGF-β signaling pathways between THBS2⁺ CAFs and THBS2^- CAFs in dataset GSE16655. THBS2⁺ CAFs expressed THBS2, whereas THBS2^- CAFs did not.

Fig. S7 Relationship between the expression of THBS2 and the score of cancer-related signaling pathways in CAFs.